Synthesis, physicochemical properties, and in vitro antibacterial screening of palladium(II) complexes derived from thiosemicarbazone

Chem Biodivers. 2013 Jun;10(6):1109-19. doi: 10.1002/cbdv.201200128.

Abstract

A new series of PdII complexes derived from thiosemicarbazone has been synthesized. The synthesized PdII complexes have been characterized on the basis of elemental analyses, FT-IR, ¹H- and ¹³C-NMR, UV/VIS, and thermal studies. A square-planar geometry has been assigned around PdII ions on the basis of results obtained from UV/VIS studies. The thiosemicarbazone ligand and its PdII complexes have been screened against Gram-positive (Bacillus subtilis and Staphylococcus aureus) and Gram-negative (Escherichia coli and Pseudomonas aeruginosa) bacteria in vitro as growth-inhibiting agents, and the results revealed significant antibacterial activities.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Anti-Bacterial Agents / chemical synthesis*
  • Anti-Bacterial Agents / chemistry
  • Anti-Bacterial Agents / pharmacology
  • Coordination Complexes / chemical synthesis*
  • Coordination Complexes / chemistry
  • Coordination Complexes / pharmacology
  • Crystallography, X-Ray
  • Gram-Negative Bacteria / drug effects
  • Gram-Positive Bacteria / drug effects
  • Microbial Sensitivity Tests
  • Molecular Conformation
  • Palladium / chemistry*
  • Spectrophotometry, Ultraviolet
  • Thiosemicarbazones / chemistry*

Substances

  • Anti-Bacterial Agents
  • Coordination Complexes
  • Thiosemicarbazones
  • Palladium