Molecular epidemiology of Escherichia coli O25b-ST131 isolates causing community-acquired UTIs in Mexico

Diagn Microbiol Infect Dis. 2013 Jul;76(3):396-8. doi: 10.1016/j.diagmicrobio.2013.03.026.

Abstract

Escherichia coli is a common uropathogen causing community-acquired urinary tract infections (UTIs). Out of 4735 E. coli community-acquired UTIs, 10.2% were extended spectrum β-lactamases (ESBL)-producing. The identified ESBL types were CTX-M-15 (96.4%), SHV-2a (3%), and TLA-1 (1%). Of the isolates, 94.6% tested positive for plasmid-mediated quinolone resistance (PMQR) genes (aac(6')-lb-cr [92.1%] and qepA1 [7%] and for qnr-determinants [3.5%]). E. coli O25b-ST131 was identified in 25% of the isolates that harbor a non-conjugative 160-kb plasmid (IncFIA) containing the CTX-M-15, and all of these isolates were found to contain PMQR genes. This work can be useful in modeling the potential impact that may have on community-acquired UTIs in Mexico.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Aged, 80 and over
  • Anti-Bacterial Agents / pharmacology
  • Child
  • Child, Preschool
  • Community-Acquired Infections / epidemiology
  • Community-Acquired Infections / microbiology
  • Escherichia coli / enzymology
  • Escherichia coli / genetics*
  • Escherichia coli / isolation & purification
  • Escherichia coli Infections / epidemiology
  • Escherichia coli Infections / microbiology*
  • Female
  • Humans
  • Male
  • Mexico / epidemiology
  • Microbial Sensitivity Tests
  • Middle Aged
  • Molecular Epidemiology
  • Molecular Typing
  • Plasmids / genetics
  • Quinolones / pharmacology
  • Urinary Tract Infections / epidemiology
  • Urinary Tract Infections / microbiology*
  • Young Adult
  • beta-Lactam Resistance / genetics
  • beta-Lactamases / genetics

Substances

  • Anti-Bacterial Agents
  • Quinolones
  • beta-lactamase CTX-M-15
  • beta-Lactamases