Abstract
Escherichia coli is a common uropathogen causing community-acquired urinary tract infections (UTIs). Out of 4735 E. coli community-acquired UTIs, 10.2% were extended spectrum β-lactamases (ESBL)-producing. The identified ESBL types were CTX-M-15 (96.4%), SHV-2a (3%), and TLA-1 (1%). Of the isolates, 94.6% tested positive for plasmid-mediated quinolone resistance (PMQR) genes (aac(6')-lb-cr [92.1%] and qepA1 [7%] and for qnr-determinants [3.5%]). E. coli O25b-ST131 was identified in 25% of the isolates that harbor a non-conjugative 160-kb plasmid (IncFIA) containing the CTX-M-15, and all of these isolates were found to contain PMQR genes. This work can be useful in modeling the potential impact that may have on community-acquired UTIs in Mexico.
Copyright © 2013 Elsevier Inc. All rights reserved.
Publication types
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Adolescent
-
Adult
-
Aged
-
Aged, 80 and over
-
Anti-Bacterial Agents / pharmacology
-
Child
-
Child, Preschool
-
Community-Acquired Infections / epidemiology
-
Community-Acquired Infections / microbiology
-
Escherichia coli / enzymology
-
Escherichia coli / genetics*
-
Escherichia coli / isolation & purification
-
Escherichia coli Infections / epidemiology
-
Escherichia coli Infections / microbiology*
-
Female
-
Humans
-
Male
-
Mexico / epidemiology
-
Microbial Sensitivity Tests
-
Middle Aged
-
Molecular Epidemiology
-
Molecular Typing
-
Plasmids / genetics
-
Quinolones / pharmacology
-
Urinary Tract Infections / epidemiology
-
Urinary Tract Infections / microbiology*
-
Young Adult
-
beta-Lactam Resistance / genetics
-
beta-Lactamases / genetics
Substances
-
Anti-Bacterial Agents
-
Quinolones
-
beta-lactamase CTX-M-15
-
beta-Lactamases