The physicochemical properties of a new class of anticancer fungal polysaccharides: a comparative study

Abstract

The structural and physicochemical properties of polysaccharides isolated from fungi with anticancer properties were investigated. The majority of the polysaccharides considered, have the β-d-Glcp component mostly connected by 1→3 and 1→6 linkages in the backbones and the short branches, respectively. The established parameters of lead-like, drug-like and of known dug space (KDS) were used and the repeating units of the polysaccharides exhibit some overlap with these. It was found that a unique region of chemical space is occupied by the polysaccharides, with MW: 1.0 x 10(5) to 2.5 x 10(5) g mol(-1); LogP: -3.0 x 10(3) to -1.0 x 10(3); HD: 1.0 x 10(3) to 5.0 x 10(3); HA: 5.0 x 10(3) to 1.0 x 10(4); PSA: 5.0 x 10(4) to 1.0 x 10(5) and RB: 5.0 x 10(3) to 1.0 x 10(4). These findings can be exploited in antitumor drug discovery projects.