Abstract
Annexin A1 (Anxa1) is a highly specific surface marker of tumor vasculature. We used peptide-displaying phage technology to identify a carbohydrate ligand-mimicking 7-mer peptide, IFLLWQR (IF7), which can target Anxa1 in tumor vasculature. Here, we describe the binding activity of carbohydrate to Anxa1, Anxa1 to heparan sulfates, and the therapeutic potential of IF7 conjugated with anticancer drugs in tumor targeting.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, Non-P.H.S.
MeSH terms
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Amino Acid Sequence
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Animals
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Annexin A1 / metabolism*
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Antineoplastic Agents / administration & dosage*
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Antineoplastic Agents / chemistry
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Antineoplastic Agents / therapeutic use
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Carbohydrate Metabolism
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Carbohydrates / chemistry
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Cell Line, Tumor
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Drug Delivery Systems*
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Female
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Fluorescent Dyes / chemistry
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Heparitin Sulfate / metabolism
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Humans
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Mice
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Neoplasms / blood supply
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Neoplasms / drug therapy*
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Neoplasms / metabolism*
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Peptides / chemistry
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Peptides / metabolism*
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Protein Binding
Substances
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Annexin A1
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Antineoplastic Agents
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Carbohydrates
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Fluorescent Dyes
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Peptides
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Heparitin Sulfate