Stereoselective synthesis of dienyl-carboxylate building blocks: formal synthesis of inthomycin C

Org Lett. 2013 Jul 5;15(13):3242-5. doi: 10.1021/ol401226y. Epub 2013 Jun 13.

Abstract

A direct synthesis of stereodefined halodienes is reported. Those key building blocks enable a concise access to polyenic products, as demonstrated in a modular synthesis of Inthomycin C.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Alkenes / chemical synthesis*
  • Alkenes / chemistry*
  • Carboxylic Acids / chemical synthesis*
  • Carboxylic Acids / chemistry
  • Hydrocarbons, Halogenated / chemical synthesis*
  • Hydrocarbons, Halogenated / chemistry*
  • Molecular Structure
  • Oxazoles / chemical synthesis*
  • Oxazoles / chemistry*
  • Stereoisomerism

Substances

  • Alkenes
  • Carboxylic Acids
  • Hydrocarbons, Halogenated
  • Oxazoles
  • inthomycin C