Abstract
Peripheral myelination is a dynamic process orchestrated by axons and Schwann cells. Although the signaling mechanisms governing myelination are not fully understood, NF-κB activation in Schwann cells has been implicated as a key regulator in vitro. Using a mouse model, we show that nuclear factor κB activation in Schwann cells is not required for myelination in vivo.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Animals, Newborn
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Cells, Cultured
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Cerebral Cortex / enzymology
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Disease Models, Animal
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Embryo, Mammalian
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Gene Expression Regulation, Enzymologic / genetics
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I-kappa B Kinase / deficiency
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I-kappa B Kinase / genetics
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Male
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Mice
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Mice, Inbred C57BL
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Mice, Knockout
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Myelin Basic Protein
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Myelin P0 Protein / genetics
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Myelin P0 Protein / metabolism
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Myelin Sheath / metabolism*
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NF-kappa B / metabolism*
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Nerve Growth Factors / metabolism
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Proteins / genetics
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Proteins / metabolism
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RNA, Untranslated
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S100 Calcium Binding Protein beta Subunit
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S100 Proteins / metabolism
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Schwann Cells / enzymology*
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Schwann Cells / metabolism
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Sciatic Nerve / metabolism
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Sciatic Nerve / pathology
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Sciatic Neuropathy / complications
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Sciatic Neuropathy / pathology
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Time Factors
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Wallerian Degeneration / etiology
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Wallerian Degeneration / pathology
Substances
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Gt(ROSA)26Sor non-coding RNA, mouse
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Mpz protein, mouse
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Myelin Basic Protein
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Myelin P0 Protein
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NF-kappa B
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Nerve Growth Factors
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Proteins
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RNA, Untranslated
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S100 Calcium Binding Protein beta Subunit
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S100 Proteins
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I-kappa B Kinase