Real-time PCR as a prognostic tool for human congenital toxoplasmosis

J Clin Microbiol. 2013 Aug;51(8):2766-8. doi: 10.1128/JCM.00982-13. Epub 2013 Jun 12.

Abstract

Real-time PCR (qPCR) was positive in 72/150 (48%) blood samples of newborns with congenital toxoplasmosis. Among infants with active retinochoroiditis, 68% had positive qPCR results, while positivity was 29% (P=0.009) in the absence of ocular involvement. Positive qPCR was associated with the presence of retinochoroidal lesions, with an odds ratio of 2.8.

Publication types

  • Evaluation Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Blood / parasitology
  • Choroiditis / etiology
  • Humans
  • Infant
  • Infant, Newborn
  • Molecular Diagnostic Techniques / methods*
  • Parasitology / methods*
  • Real-Time Polymerase Chain Reaction / methods*
  • Toxoplasmosis, Congenital / diagnosis*