The aim of this study was to assess self-perceived quality of life of people with physical disabilities from the perspective of work. The following tools were used in the study: a personal questionnaire, an SF-36v2 questionnaire, an I-E Scale at Work and a Polish adaptation of the Ferrans and Powers Quality of Life Index. The study involved 426 disabled persons aged 18-65. It demonstrated that quality of life depends, to a large extent, on factors such as age and labour force participation. Duration of looking for work had a significant influence on the satisfaction from the psychological perspective and on the perception of general health. For the respondents who were unemployed and not looking for work, quality of life decreased with increased duration of professional inactivity.