Abstract
We investigated the efficacy on recovery of function following controlled cortical ischemia in the monkey of the investigational cell drug product, CNTO 0007. This drug contains a cellular component, human umbilical tissue-derived cells, in a proprietary thaw and inject formulation. Results demonstrate significantly better recovery of motor function in the treatment group with no difference between groups in the volume or surface area of ischemic damage, suggesting that the cells stimulated plasticity.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Brain Ischemia / complications
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Brain Ischemia / pathology*
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Brain Ischemia / surgery*
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Cell- and Tissue-Based Therapy / methods*
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Disease Models, Animal
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Electroencephalography
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Functional Laterality / physiology
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Hand Strength / physiology
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Macaca mulatta
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Male
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Motor Cortex / physiology*
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Motor Skills / physiology*
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Movement Disorders / etiology
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Movement Disorders / surgery
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Recovery of Function / physiology*
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Single-Blind Method
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Upper Extremity / physiopathology