Abstract
It was investigated whether a standard mouse diet (AIN-76A) supplemented with walnuts reduced the establishment and growth of LNCaP human prostate cancer cells in nude (nu/nu) mice. The walnut-enriched diet reduced the number of tumors and the growth of the LNCaP xenografts; 3 of 16 (18.7%) of the walnut-fed mice developed tumors; conversely, 14 of 32 mice (44.0%) of the control diet-fed animals developed tumors. Similarly, the xenografts in the walnut-fed animals grew more slowly than those in the control diet mice. The final average tumor size in the walnut-diet animals was roughly one-fourth the average size of the prostate tumors in the mice that ate the control diet.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Adenocarcinoma / drug therapy*
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Adenocarcinoma / metabolism
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Adenocarcinoma / pathology
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Animals
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Antineoplastic Agents, Phytogenic / administration & dosage*
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Cell Line, Tumor
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F2-Isoprostanes / metabolism
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Humans
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Juglans*
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Lipid Peroxidation
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Liver / metabolism
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Male
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Mice
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Mice, Nude
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Oxidative Stress
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Phytotherapy
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Plant Preparations / administration & dosage*
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Prostate-Specific Antigen / metabolism
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Prostatic Neoplasms / drug therapy*
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Prostatic Neoplasms / metabolism
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Prostatic Neoplasms / pathology
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Tumor Burden
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Xenograft Model Antitumor Assays
Substances
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Antineoplastic Agents, Phytogenic
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F2-Isoprostanes
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Plant Preparations
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Prostate-Specific Antigen