Abstract
Varicella-zoster virus (VZV) resistance to acyclovir (ACV) has only been reported in rare cases of immunocompromised patients. We report the first case of an immunocompetent patient with ACV-resistant VZV keratitis associated with a nucleotide deletion in the VZV thymidine kinase gene, leading to production of a truncated protein.
Keywords:
Acyclovir; Cornea; Drug resistance; Herpetic keratitis; Varicella zoster virus.
Copyright © 2013 Elsevier B.V. All rights reserved.
MeSH terms
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Acyclovir / pharmacology
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Acyclovir / therapeutic use*
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Antiviral Agents / pharmacology
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Antiviral Agents / therapeutic use*
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Drug Resistance, Viral*
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Herpesvirus 3, Human / drug effects*
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Herpesvirus 3, Human / genetics
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Humans
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Immunocompromised Host*
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Keratitis, Herpetic / drug therapy*
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Keratitis, Herpetic / virology*
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Male
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Middle Aged
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Mutant Proteins / genetics
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Sequence Deletion
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Thymidine Kinase / genetics
Substances
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Antiviral Agents
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Mutant Proteins
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Thymidine Kinase
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Acyclovir