Abstract
Here we studied the N-triethylene glycol (N-TEG) group as a surrogate for the N-Me group in Sansalvamide A peptide. The five N-TEG and N-Me analogs of this cyclic pentapeptide were synthesized, and their biological activity, lipophilicity and conformational features were compared.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Antineoplastic Agents / chemistry*
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Antineoplastic Agents / pharmacology
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Cell Line, Tumor
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Cell Survival / drug effects
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Depsipeptides / chemistry*
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Depsipeptides / pharmacology
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Humans
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Polyethylene Glycols / chemistry*
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Polyethylene Glycols / pharmacology
Substances
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Antineoplastic Agents
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Depsipeptides
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sansalvamide A
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triethylene glycol
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Polyethylene Glycols