N-Triethylene glycol (N-TEG) as a surrogate for the N-methyl group: application to Sansalvamide A peptide analogs

Chem Commun (Camb). 2013 Jul 21;49(57):6430-2. doi: 10.1039/c3cc41788c.

Abstract

Here we studied the N-triethylene glycol (N-TEG) group as a surrogate for the N-Me group in Sansalvamide A peptide. The five N-TEG and N-Me analogs of this cyclic pentapeptide were synthesized, and their biological activity, lipophilicity and conformational features were compared.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antineoplastic Agents / chemistry*
  • Antineoplastic Agents / pharmacology
  • Cell Line, Tumor
  • Cell Survival / drug effects
  • Depsipeptides / chemistry*
  • Depsipeptides / pharmacology
  • Humans
  • Polyethylene Glycols / chemistry*
  • Polyethylene Glycols / pharmacology

Substances

  • Antineoplastic Agents
  • Depsipeptides
  • sansalvamide A
  • triethylene glycol
  • Polyethylene Glycols