Abstract
Genetic determinants of a bla(NDM-1)-positive, multidrug-resistant bacterial isolate that caused active infection was investigated by DNA sequencing. Two plasmids, pKOX_NDM1 and pKOX-R1, were identified for the Klebsiella oxytoca strain E718. Sequence annotation revealed a bla(NDM-1) gene in pKOX_NDM1 and two extended-spectrum β-lactamase producers (bla(CTX-M-3) and blaSHV-12) and a wide array of resistance genes in pKOX-R1. These findings highlight the difficulty in treating multidrug-resistant bacterial infections and the potential danger of emerging resistant enterobacteria.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Aminoglycosides / pharmacology
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Anti-Bacterial Agents / pharmacology
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Conjugation, Genetic
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Escherichia coli / genetics
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Escherichia coli / metabolism
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Genes, Bacterial*
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Genes, MDR
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Humans
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Klebsiella Infections / diagnosis
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Klebsiella oxytoca / drug effects
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Klebsiella oxytoca / enzymology
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Klebsiella oxytoca / genetics*
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Klebsiella oxytoca / isolation & purification
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Microbial Sensitivity Tests
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Plasmids / genetics*
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Taiwan
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beta-Lactamases / genetics*
Substances
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Aminoglycosides
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Anti-Bacterial Agents
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beta-lactamase CTX-M-3
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beta-lactamase SHV-12
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beta-Lactamases
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beta-lactamase NDM-1