CTX-M-123, a novel hybrid of the CTX-M-1 and CTX-M-9 Group β-lactamases recovered from Escherichia coli isolates in China

Antimicrob Agents Chemother. 2013 Aug;57(8):4068-71. doi: 10.1128/AAC.00541-13. Epub 2013 Jun 10.

Abstract

The chimeric bla(CTX-M-123) gene was identified in two ceftazidime-resistant Escherichia coli isolates from animals in different Chinese provinces. Like other CTX-M-1/9 group hybrids (CTX-M-64 and CTX-M-132), the ends (amino acids 1 to 135 and 234 to 291) of CTX-M-123 match CTX-M-15 while the central part (122 to 241) matches CTX-M-14. bla(CTX-M-123) is carried on related, but not identical, ~90-kb IncI1 plasmids in the two isolates, and one isolate simultaneously carries the group 1 blaCTX-M-55 gene on an additional IncI2 plasmid.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Bacterial Proteins / genetics
  • Bacterial Proteins / metabolism
  • Base Sequence
  • Ceftazidime / pharmacology
  • China
  • Escherichia coli / drug effects
  • Escherichia coli / enzymology*
  • Escherichia coli / genetics
  • Escherichia coli Proteins / classification
  • Escherichia coli Proteins / genetics
  • Escherichia coli Proteins / metabolism*
  • Genes, Bacterial*
  • Homologous Recombination
  • Microbial Sensitivity Tests
  • Molecular Sequence Data
  • Mutant Chimeric Proteins / genetics
  • Mutant Chimeric Proteins / metabolism*
  • Plasmids / genetics
  • Plasmids / metabolism
  • beta-Lactamases / classification
  • beta-Lactamases / genetics
  • beta-Lactamases / metabolism*

Substances

  • Bacterial Proteins
  • Escherichia coli Proteins
  • Mutant Chimeric Proteins
  • Ceftazidime
  • CTX-M-9 protein, E coli
  • beta-lactamase TEM-3
  • beta-Lactamases

Associated data

  • GENBANK/JN790864
  • GENBANK/KC160505
  • GENBANK/KC576516
  • GENBANK/KC576517