Abstract
We identified epicatechin-(4 β → 6)-epicatechin-(2 β → O → 7, 4 β → 8)-catechin (EEC) in the skin of the peanut (Arachis hypogaea L.). EEC (a trimer) showed more potent cholesterol micelle-degrading activity than procyanidin A1 (a dimer) did in vitro. The hypercholesterolemia suppressing effect of a peanut skin polyphenol on rats fed high-cholesterol diet in our preceding experiments might thus have been due primarily to a micelle degrading effect in the intestine.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Anthocyanins / administration & dosage*
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Antioxidants / administration & dosage
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Arachis / chemistry*
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Catechin / administration & dosage
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Catechin / analogs & derivatives*
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Cholesterol / blood*
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Humans
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Hypercholesterolemia / drug therapy*
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Hypercholesterolemia / metabolism
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Male
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Micelles
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Polyphenols / administration & dosage
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Proanthocyanidins / administration & dosage
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Rats
Substances
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Anthocyanins
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Antioxidants
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Micelles
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Polyphenols
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Proanthocyanidins
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epicatechin-(4beta-8)-epicatechin-(4beta-8,2beta-O-7)-epicatechin-(4beta-8)-epicatechin
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procyanidin A1
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Catechin
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Cholesterol