Abstract
The circadian clock can regulate the metabolic process of xenobiotics, but little is known as to circadian rhythms can be perturbed by xenobiotics. Styrene is a organic chemical widely used in occupational settings. The effects of styrene on the circadian genes of HuDE cells were evaluated after serum-shocking synchronization. A subtoxic dose of 100 µM of styrene altered the expression of clock genes BMAL1, PER2, PER3, CRY1, CRY2, and REV-ERB-α.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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ARNTL Transcription Factors / biosynthesis
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Cells, Cultured
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Circadian Rhythm / drug effects*
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Circadian Rhythm / genetics
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Cryptochromes / biosynthesis
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Fibroblasts / drug effects*
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Gene Expression Regulation, Developmental / drug effects*
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Humans
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Nuclear Receptor Subfamily 1, Group D, Member 1 / biosynthesis
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Period Circadian Proteins / biosynthesis
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Styrene / administration & dosage*
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Xenobiotics / administration & dosage
Substances
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ARNTL Transcription Factors
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BMAL1 protein, human
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CRY1 protein, human
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CRY2 protein, human
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Cryptochromes
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NR1D1 protein, human
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Nuclear Receptor Subfamily 1, Group D, Member 1
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PER2 protein, human
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PER3 protein, human
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Period Circadian Proteins
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Xenobiotics
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Styrene