No association between AKT1 gene variants and schizophrenia: a Malaysian case-control study and meta-analysis

Han Chern Loh; Tze Jen Chow; Pek Yee Tang; Hoi Sen Yong

doi:10.1016/j.psychres.2013.05.017

No association between AKT1 gene variants and schizophrenia: a Malaysian case-control study and meta-analysis

Psychiatry Res. 2013 Oct 30;209(3):732-3. doi: 10.1016/j.psychres.2013.05.017. Epub 2013 Jun 5.

Authors

Han Chern Loh¹, Tze Jen Chow, Pek Yee Tang, Hoi Sen Yong

Affiliation

¹ Department of Chemical Engineering, Faculty of Engineering and Science (FES), Universiti Tunku Abdul Rahman (UTAR), Jalan Genting Kelang, Setapak, 53300 Kuala Lumpur, Malaysia; High Impact Research Office, Level 9, Chancellery Building, University of Malaya (UM), 50603 Kuala Lumpur, Malaysia. Electronic address: hcloh@utar.edu.my.

PMID: 23747160
DOI: 10.1016/j.psychres.2013.05.017

Abstract

We aim to replicate AKT1 gene variants studies using Malaysian samples. Seven AKT1 single nucleotide polymorphisms (SNPs) were studied in 417 patients and 429 controls. Haplotype showed significant association (p=0.036) with schizophrenia, especially in Malays and Indians. Meta-analysis of rs2494732 showed significant association worldwide (p=0.018) and in Asians (p=0.023).

Keywords: Ethnic analysis; Haplotype; rs2494732.

Publication types

Meta-Analysis
Research Support, Non-U.S. Gov't

MeSH terms

Adult
Female
Genetic Association Studies
Genotype
Humans
Malaysia / epidemiology
Malaysia / ethnology
Male
Middle Aged
Polymorphism, Single Nucleotide
Proto-Oncogene Proteins c-akt / genetics*
Reference Values
Schizophrenia / ethnology
Schizophrenia / genetics*
Young Adult

Substances

AKT1 protein, human
Proto-Oncogene Proteins c-akt