Abstract
Adrenomedullin (AM) is a 52-amino acid peptide initially isolated from human pheochromocytoma. AM is expressed in a variety of malignant tissues and cancer cell lines and was shown to be a mitogenic factor capable of stimulating growth of several cancer cell types. In addition, AM is a survival factor for certain cancer cells. Some data suggest that AM might be involved in the progression cancer metastasis via angiogenesis and cell migration and invasion control. The Transient Receptor Potential channel TRPV2 is known to promote in prostate cancer cell migration and invasive phenotype and is correlated with the stage and grade of bladder cancer. In this work we show that AM induces prostate and urothelial cancer cell migration and invasion through TRPV2 translocation to plasma membrane and the subsequent increase in resting calcium level.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Adrenomedullin / pharmacology*
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Cell Adhesion / drug effects
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Cell Adhesion / genetics
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Cell Line, Tumor
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Cell Membrane / metabolism
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Cell Movement / drug effects
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Cell Movement / genetics
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Humans
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Male
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Neoplasm Invasiveness
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Phosphatidylinositol 3-Kinases / metabolism
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Prostatic Neoplasms / genetics*
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Prostatic Neoplasms / metabolism*
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Prostatic Neoplasms / pathology*
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Protein Transport
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Signal Transduction
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TRPV Cation Channels / genetics*
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TRPV Cation Channels / metabolism
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Urethral Neoplasms / genetics*
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Urethral Neoplasms / metabolism*
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Urethral Neoplasms / pathology
Substances
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TRPV Cation Channels
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TRPV2 protein, human
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Adrenomedullin
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Phosphatidylinositol 3-Kinases
Grants and funding
This work was supported by grants from the Institut National de la Sante et de la Recherche Medicale (INSERM), Ligue Nationale Contre le Cancer, Region Nord Pas de Calais and Université Catholique de Lille. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.