Chronic valproic acid intoxication

Pediatr Emerg Care. 2013 Jun;29(6):756-7. doi: 10.1097/PEC.0b013e318294f558.

Abstract

Valproic acid intoxication may be associated with cerebral, cardiovascular, respiratory, gastrointestinal, and hematologic complications. We report a case of a 7-year-old girl, epilepsy-treated chronically with valproic acid, sulthiame, and clonazepam, who presented to the emergency room because of a global deterioration during the preceding 2 months, including poorer feeding and worsened general responsiveness. The girl was later diagnosed to have chronic valproic acid intoxication.

Publication types

  • Case Reports

MeSH terms

  • Anticonvulsants / administration & dosage
  • Anticonvulsants / poisoning*
  • Cerebral Palsy / complications
  • Chemistry, Pharmaceutical
  • Child
  • Chronic Disease
  • Developmental Disabilities / complications
  • Dose-Response Relationship, Drug
  • Drug Overdose / etiology*
  • Epilepsy / complications
  • Epilepsy / drug therapy
  • Female
  • Humans
  • Lethargy / chemically induced*
  • Medication Errors*
  • Quadriplegia / complications
  • Thrombocytopenia / chemically induced
  • Valproic Acid / administration & dosage
  • Valproic Acid / poisoning*

Substances

  • Anticonvulsants
  • Valproic Acid