Intracellular observation of nanocarriers modified with a mitochondrial targeting signal peptide

Eriko Kawamura; Yuma Yamada; Yukari Yasuzaki; Mamoru Hyodo; Hideyoshi Harashima

doi:10.1016/j.jbiosc.2013.05.001

Intracellular observation of nanocarriers modified with a mitochondrial targeting signal peptide

J Biosci Bioeng. 2013 Nov;116(5):634-7. doi: 10.1016/j.jbiosc.2013.05.001. Epub 2013 Jun 2.

Authors

Eriko Kawamura¹, Yuma Yamada, Yukari Yasuzaki, Mamoru Hyodo, Hideyoshi Harashima

Affiliation

¹ Laboratory for Molecular Design of Pharmaceutics, Faculty of Pharmaceutical Sciences, Hokkaido University, Kita-12, Nishi-6, Kita-ku, Sapporo 060-0812, Japan.

PMID: 23735326
DOI: 10.1016/j.jbiosc.2013.05.001

Abstract

This study focused on the intracellular observation of nanocarriers modified with a mitochondrial targeting signal peptide (MTS). The nanocarriers showed an efficient cellular uptake, and the MTS had a positive effect on their mitochondrial targeting. This is the first report of an intracellular observation of nanocarriers modified with MTS.

Keywords: MITO-Porter; Mitochondria; Mitochondrial drug delivery; Mitochondrial targeting signal peptide (MTS); Nanocarriers; Nanotechnology.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Drug Carriers / analysis
Drug Carriers / metabolism
Drug Delivery Systems
HeLa Cells
Humans
Intracellular Space / metabolism*
Mitochondria / metabolism*
Nanomedicine
Nanostructures / analysis*
Nanostructures / chemistry
Protein Sorting Signals*
Substrate Specificity

Substances

Drug Carriers
Protein Sorting Signals