Natural killer expansion, human leukocyte antigens-E expression and CD14(+) CD56(+) monocytes in a myelodysplastic syndrome patient

Eur J Haematol. 2013 Sep;91(3):265-269. doi: 10.1111/ejh.12152. Epub 2013 Jun 28.

Abstract

Myelodysplastic syndromes (MDS) are clonal disorders characterized by ineffective hematopoiesis and possible evolution to acute leukemia. Occurrence of stem cell defects and of immune-mediated mechanisms was evidenced as relevant for pathophysiology of MDS. Here, we described one case of MDS patient carrying CD14(+) CD56(+) monocytes in bone marrow (BM), in the presence of a defective human leukocyte antigen (HLA)-E expression on peripheral blood (PB) cells and of natural killer (NK) cell expansion in PB and BM. The defective HLA-E expression and the NK expansion are proposed to be relevant for the pathogenesis of myelodysplasia in those patients showing CD14(+) CD56(+) monocytes in BM.

Keywords: CD94/NKG2 receptors; human leukocyte antigens-E; immune-mediated etiopathogenesis; myelodysplastic syndromes; natural killer.

Publication types

  • Case Reports
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged, 80 and over
  • Antigens, CD / metabolism
  • CD56 Antigen / metabolism
  • HLA-E Antigens
  • Histocompatibility Antigens Class I / immunology
  • Histocompatibility Antigens Class I / metabolism*
  • Humans
  • Immunophenotyping
  • Killer Cells, Natural / cytology
  • Killer Cells, Natural / immunology*
  • Lipopolysaccharide Receptors / metabolism
  • Male
  • Monocytes / immunology*
  • Monocytes / metabolism*
  • Myelodysplastic Syndromes / genetics
  • Myelodysplastic Syndromes / immunology*
  • Myelodysplastic Syndromes / metabolism*

Substances

  • Antigens, CD
  • CD56 Antigen
  • Histocompatibility Antigens Class I
  • Lipopolysaccharide Receptors