Abstract
Studies in recent years suggest a role for inflammation, proinflammatory cytokines in particular, the development of microvascular complications of diabetes, including nephropathy. We investigated the expression of IL-6 in the biopsy tissue kidneys (in glomeruli and interstitium) in 24 elderly patients with type 2 diabetes complicated by diabetic nephropathy. The significant influence of intrarenal expression of IL-6 on the development of morphological (glomerular and tubulointerstitial) changes in renal tissue in patients with diabetic nephropathy is shown.
MeSH terms
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Aged
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Diabetes Mellitus, Type 2 / immunology
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Diabetes Mellitus, Type 2 / metabolism
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Diabetes Mellitus, Type 2 / pathology*
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Diabetic Nephropathies / immunology
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Diabetic Nephropathies / metabolism
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Diabetic Nephropathies / pathology*
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Endothelium, Vascular / immunology
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Endothelium, Vascular / metabolism
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Endothelium, Vascular / pathology
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Female
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Humans
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Interleukin-6 / biosynthesis
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Interleukin-6 / physiology*
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Kidney / blood supply
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Kidney / immunology
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Kidney / metabolism
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Kidney / pathology*
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Kidney Function Tests
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Male
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Microscopy, Fluorescence
Substances
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IL6 protein, human
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Interleukin-6