Triterpenes with cytotoxicity from the leaves of Vernicia fordii

Chem Pharm Bull (Tokyo). 2013;61(6):674-7. doi: 10.1248/cpb.c13-00055.

Abstract

Two new triterpenes, (1α,3β,8α,9β,10α,13α,14β)-9,10-dimethyl-25,26-dinorolean-5-en-1,3-diol (1) and (1α,3β,6β)-olean-12-en-1,3,6-triol (2) were isolated from the leaves of Aleurites fordii, together with five known triterpenes. The structures of isolates were established by one dimensional (1D)- and 2D-NMR spectroscopic data along with MS analysis. Of the isolated compounds, 1, 2 and 4 (daturadiol) displayed moderate cytotoxicities against two or more human cancer cell lines in HepG2 (hepatocellular carcinoma), SK-OV-3 (ovarian carcinoma), A-549 (lung carcinoma) and SNU-1 (gastric carcinoma).

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Cell Line, Tumor
  • Cell Survival / drug effects
  • Euphorbiaceae / chemistry*
  • Hep G2 Cells
  • Humans
  • Magnetic Resonance Spectroscopy
  • Molecular Conformation
  • Plant Leaves / chemistry
  • Triterpenes / chemistry*
  • Triterpenes / isolation & purification
  • Triterpenes / toxicity

Substances

  • (1alpha,3beta,6beta)-olean-12-en-1,3,6-triol
  • (1alpha,3beta,8alpha,9beta,10alpha,13alpha,14beta)-9,10-dimethyl-25,26-dinorolean-5-en-1,3-diol
  • Triterpenes