Genomic mosaicism in two strains of Dengue virus type 3

Christian Julián Villabona-Arenas; Anderson Fernandes de Brito; Paolo Marinho de Andrade Zanotto

doi:10.1016/j.meegid.2013.05.012

Genomic mosaicism in two strains of Dengue virus type 3

Infect Genet Evol. 2013 Aug:18:202-12. doi: 10.1016/j.meegid.2013.05.012. Epub 2013 May 30.

Authors

Christian Julián Villabona-Arenas¹, Anderson Fernandes de Brito, Paolo Marinho de Andrade Zanotto

Affiliation

¹ Laboratory of Molecular Evolution and Bioinformatics, Department of Microbiology, Institute of Biomedical Sciences, University of São Paulo, Av. Prof. Lineu Prestes 1734, CEP: 05508-000, São Paulo, SP, Brazil.

PMID: 23727343
DOI: 10.1016/j.meegid.2013.05.012

Abstract

Recombination is a significant factor driving genomic evolution, but it is not well understood in Dengue virus. We used phylogenetic methods to search for recombination in 636 Dengue virus type 3 (DENV-3) genomes and unveiled complex recombination patterns in two strains, which appear to be the outcome of recombination between genotype II and genotype I parental DENV-3 lineages. Our findings of genomic mosaic structures suggest that strand switching during RNA synthesis may be involved in the generation of genetic diversity in dengue viruses.

Keywords: Dengue virus type 3; Phylogeny; Recombination; Split decomposition.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Bayes Theorem
Dengue Virus / classification
Dengue Virus / genetics*
Evolution, Molecular
Genome, Viral*
Phylogeny
Recombination, Genetic