Resveratrol derived butyrylcholinesterase inhibitors

Arch Pharm (Weinheim). 2013 Jul;346(7):499-503. doi: 10.1002/ardp.201300051. Epub 2013 May 30.

Abstract

Novel polyhydroxylated (E)-stilbenes were synthesized by Mizoroki-Heck reactions and tested for their ability to inhibit the enzymes acetyl- and butyrylcholinesterase. Several of them are good inhibitors of butyrylcholinesterase; one of them carrying an extra fluorine substituent is a 94-fold stronger inhibitor of butyrylcholinesterase than of acetylcholinesterase.

Keywords: Acetylcholinesterase; Alzheimer disease; Butyrylcholinesterase; Resveratrol analogs.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acetylcholinesterase / metabolism
  • Butyrylcholinesterase / metabolism*
  • Cholinesterase Inhibitors / chemical synthesis
  • Cholinesterase Inhibitors / pharmacology*
  • Molecular Structure
  • Resveratrol
  • Stilbenes / chemical synthesis
  • Stilbenes / pharmacology*
  • Structure-Activity Relationship

Substances

  • Cholinesterase Inhibitors
  • Stilbenes
  • Acetylcholinesterase
  • Butyrylcholinesterase
  • Resveratrol