Orthogonal adsorption onto nano-graphene oxide using different intermolecular forces for multiplexed delivery

Feng Wang; Biwu Liu; Alexander C-F Ip; Juewen Liu

doi:10.1002/adma.201301183

Orthogonal adsorption onto nano-graphene oxide using different intermolecular forces for multiplexed delivery

Adv Mater. 2013 Aug 14;25(30):4087-92. doi: 10.1002/adma.201301183. Epub 2013 May 31.

Authors

Feng Wang¹, Biwu Liu, Alexander C-F Ip, Juewen Liu

Affiliation

¹ Department of Chemistry and Waterloo Institute for Nanotechnology, University of Waterloo, 200 University Avenue West, Waterloo, Ontario, Canada.

PMID: 23722422
DOI: 10.1002/adma.201301183

Abstract

Nano-graphene oxide can adsorb both doxorubicin and zwitterionic dioleoyl-sn-glycero-3-phosphocholine (DOPC) liposomes in an orthogonal and non-competing manner with high capacities based on different surface and intermolecular forces taking place on the heterogeneous surface of the graphene oxide. The system forms stable colloids, allowing co-delivery of both cargos to cancer cells.

Keywords: adsorption; drug delivery; graphene oxide; liposomes.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Adsorption
Cell Survival / drug effects
Diffusion
Doxorubicin / administration & dosage
Doxorubicin / chemistry*
Doxorubicin / pharmacokinetics*
Graphite / chemistry*
HeLa Cells
Humans
Materials Testing
Nanocapsules / administration & dosage*
Nanocapsules / chemistry*
Nanocapsules / ultrastructure
Oxides / chemistry
Particle Size
Phosphatidylcholines / chemistry*
Stress, Mechanical

Substances

Nanocapsules
Oxides
Phosphatidylcholines
Graphite
Doxorubicin
1,2-oleoylphosphatidylcholine