Abstract
This article provides a comprehensive, up to date summary of the effects of volatile, gaseous, and intravenous anesthetics and opioid agonists on ventilatory control. Emphasis is placed on data from human studies. Further mechanistic insights are provided by in vivo and in vitro data from other mammalian species. The focus is on the effects of clinically relevant agonist concentrations and studies using pharmacological, that is, supraclinical agonist concentrations are de-emphasized or excluded.
© 2012 American Physiological Society
Publication types
-
Research Support, N.I.H., Extramural
-
Research Support, Non-U.S. Gov't
-
Review
MeSH terms
-
Analgesics, Opioid / pharmacology*
-
Anesthetics, General / pharmacology*
-
Animals
-
Carotid Body / drug effects
-
Chemoreceptor Cells / drug effects
-
Dose-Response Relationship, Drug
-
Humans
-
Hypnotics and Sedatives / pharmacology*
-
Ion Channels / drug effects
-
Models, Animal
-
Motor Neurons / drug effects
-
Respiratory Center / drug effects
-
Respiratory Center / physiology
-
Respiratory Mechanics / drug effects*
-
Respiratory Mechanics / physiology
-
Synaptic Transmission / drug effects
Substances
-
Analgesics, Opioid
-
Anesthetics, General
-
Hypnotics and Sedatives
-
Ion Channels