Effects of anesthetics, sedatives, and opioids on ventilatory control

Compr Physiol. 2012 Oct;2(4):2281-367. doi: 10.1002/cphy.c100061.

Abstract

This article provides a comprehensive, up to date summary of the effects of volatile, gaseous, and intravenous anesthetics and opioid agonists on ventilatory control. Emphasis is placed on data from human studies. Further mechanistic insights are provided by in vivo and in vitro data from other mammalian species. The focus is on the effects of clinically relevant agonist concentrations and studies using pharmacological, that is, supraclinical agonist concentrations are de-emphasized or excluded.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Analgesics, Opioid / pharmacology*
  • Anesthetics, General / pharmacology*
  • Animals
  • Carotid Body / drug effects
  • Chemoreceptor Cells / drug effects
  • Dose-Response Relationship, Drug
  • Humans
  • Hypnotics and Sedatives / pharmacology*
  • Ion Channels / drug effects
  • Models, Animal
  • Motor Neurons / drug effects
  • Respiratory Center / drug effects
  • Respiratory Center / physiology
  • Respiratory Mechanics / drug effects*
  • Respiratory Mechanics / physiology
  • Synaptic Transmission / drug effects

Substances

  • Analgesics, Opioid
  • Anesthetics, General
  • Hypnotics and Sedatives
  • Ion Channels