The research of reactions to disasters is uncommon. Moreover, most studies target a specific population, whether civilians or professionals. The aim of this study was to compare the reactions of hospital personnel and civilians after exposure to a unique disaster that combines natural and nuclear disaster. A matching sample of nurses and civilians was compared using a brief questionnaire tapping into posttraumatic stress disorder (PTSD) symptoms, subjective health, perceived coping, life satisfaction, and meaning in life. The results revealed that the nurses had a lower level of PTSD symptoms and higher self-rated health, life satisfaction, and perceived coping in comparison with the civilians. These results are discussed in light of work characteristics that include exposure to traumatic events as part of their work and coping that is partially based on training.