[Tuberculosis of the breast]

Biomedica. 2013 Jan-Mar;33(1):36-41. doi: 10.1590/S0120-41572013000100005.
[Article in Spanish]

Abstract

We report a case of granulomatous mastitis caused by Mycobacterium tuberculosis in an immunocompetent woman with chronic inflammatory lesions of the breast. It was diagnosed by detection of mycobacteria DNA using polymerase chain reaction technique targeting IS6110 insertion element of M. tuberculosis complex in a paraffin-embedded histological specimen. The primary breast tuberculosis is rare, even in countries where the incidence and prevalence of pulmonary and extra pulmonary tuberculosis are high. It should be suspected in female patients with chronic granulomatous mastitis with no apparent cause. The cornerstone of treatment is antituberculous chemotherapy, and surgery is rarely required.

Publication types

  • Case Reports
  • English Abstract

MeSH terms

  • Adult
  • Anti-Bacterial Agents / therapeutic use
  • Antitubercular Agents / therapeutic use
  • Biopsy
  • Breast Neoplasms / diagnosis
  • DNA Transposable Elements / genetics
  • DNA, Bacterial / analysis
  • Dermatomycoses / diagnosis
  • Diagnosis, Differential
  • Ethambutol / therapeutic use
  • False Negative Reactions
  • Female
  • Fever / etiology
  • Humans
  • Isoniazid / therapeutic use
  • Mastitis / diagnosis*
  • Mastitis / pathology
  • Mycobacterium tuberculosis / genetics
  • Mycobacterium tuberculosis / isolation & purification
  • Pyrazinamide / therapeutic use
  • Rifampin / therapeutic use
  • Skin Diseases, Bacterial / diagnosis
  • Tuberculoma / diagnosis*
  • Tuberculoma / pathology
  • Tuberculosis, Cutaneous / diagnosis*
  • Tuberculosis, Cutaneous / pathology
  • Weight Loss

Substances

  • Anti-Bacterial Agents
  • Antitubercular Agents
  • DNA Transposable Elements
  • DNA, Bacterial
  • Pyrazinamide
  • Ethambutol
  • Isoniazid
  • Rifampin