Engineering polymeric microparticles as theranostic carriers for selective delivery and cancer therapy

Abstract

Multifunctional polymeric nano- and microparticles are engineered as theranostic carriers and their selective size-dependent cellular uptake is demonstrated. It is found that effective uptake and accumulation of nanoparticles occurs in both normal and cancer cells, whereas, that of microparticles occurs in cancer cells but not in normal cells, allowing cancer cells to be specifically targeted for local drug delivery.

Keywords: cancer therapy; microparticles; nanoparticles; selective uptake.