Surface functionalization of gold nanoparticles with red blood cell membranes

Adv Mater. 2013 Jul 12;25(26):3549-53. doi: 10.1002/adma.201300638. Epub 2013 May 27.

Abstract

Gold nanoparticles are enclosed in cellular membranes derived from natural red blood cells (RBCs) by a top-down approach. The gold nanoparticles exhibit a complete membrane surface layer and biological characteristics of the source cells. The combination of inorganic gold nanoparticles with biological membranes is a compelling way to develop biomimetic gold nanostructures for future applications, such as those requiring evasion of the immune system.

Keywords: biomimetics; gold nanoparticles; nanomedicine; red blood cells; surface functionalization.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Animals
  • Cell Line
  • Erythrocyte Membrane / metabolism*
  • Gold / chemistry*
  • Gold / metabolism*
  • Male
  • Metal Nanoparticles / chemistry*
  • Mice
  • Models, Molecular
  • Molecular Conformation
  • Phagocytes
  • Surface Properties

Substances

  • Gold