Three new ursane-type triterpenes from the leaves of Rehmannia glutinosa

Fitoterapia. 2013 Sep:89:15-9. doi: 10.1016/j.fitote.2013.05.013. Epub 2013 May 22.

Abstract

Three new ursane-type triterpenes, glutinosalactone A-C (1-3), were isolated from the 50% aqueous acetone extract of the leaves of Rehmannia glutinosa. Their structures were elucidated on the basis of spectral analysis (IR, NMR and MS spectroscopy). The cytotoxic effects of compounds 1-3 against three human cancer cell lines (MCF-7, MG63 and HepG2) were also evaluated. Compound 3 showed cytotoxic activities with IC50 values of 8.35-39.25 μM.

Keywords: Cytotoxic activity; Rehmannia glutinosa; Scrophulariaceae; Ursane-type triterpenes.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antineoplastic Agents, Phytogenic / isolation & purification*
  • Antineoplastic Agents, Phytogenic / pharmacology
  • Antineoplastic Agents, Phytogenic / therapeutic use
  • Hep G2 Cells
  • Humans
  • Inhibitory Concentration 50
  • MCF-7 Cells
  • Molecular Structure
  • Neoplasms / drug therapy*
  • Phytotherapy
  • Plant Extracts / chemistry
  • Plant Extracts / pharmacology
  • Plant Extracts / therapeutic use
  • Plant Leaves / chemistry*
  • Rehmannia / chemistry*
  • Triterpenes / chemistry
  • Triterpenes / isolation & purification*
  • Triterpenes / pharmacology
  • Triterpenes / therapeutic use

Substances

  • Antineoplastic Agents, Phytogenic
  • Plant Extracts
  • Triterpenes
  • glutinosalactone A
  • glutinosalactone B
  • glutinosalactone C