SIRT1 attenuates neointima formation by inhibiting HIF-1α expression in neointimal lesion of a murine wire-injured femoral artery

Int J Cardiol. 2013 Oct 9;168(4):4393-6. doi: 10.1016/j.ijcard.2013.05.044. Epub 2013 May 23.

Authors

Jin U Bae¹, Seung J Lee, Kyo W Seo, Yun H Kim, So Y Park, Sun S Bae, Chi D Kim

Affiliation

¹ Department of Pharmacology, School of Medicine, Pusan National University, Yangsan, Gyeongnam 626-870, Republic of Korea; MRC for Ischemic Tissue Regeneration, Pusan National University, Yangsan, Gyeongnam 626-870, Republic of Korea.

PMID: 23706319
DOI: 10.1016/j.ijcard.2013.05.044

No abstract available

Keywords: HIF-1α; Neointima; Neovascularization; Restenosis; SIRT1; VSMC.

Publication types

Letter
Research Support, Non-U.S. Gov't

MeSH terms

Animals
Cells, Cultured
Femoral Artery / pathology*
Hypoxia-Inducible Factor 1, alpha Subunit / biosynthesis*
Mice
Mice, Transgenic
Muscle, Smooth, Vascular / cytology
Neointima / etiology*
Sirtuin 1 / physiology*

Substances

Hif1a protein, mouse
Hypoxia-Inducible Factor 1, alpha Subunit
Sirt1 protein, mouse
Sirtuin 1