This paper seeks to examine differences in sociodemographic characteristics and culturally-relevant psychosocial and interpersonal factors across four sub-groups of immigrant Latinas, and how these factors are associated with adherence to age-specific breast and cervical cancer screening. Data come from a baseline survey using an electronic audience response system from a randomized controlled trial to test the effectiveness of a cancer screening program in New York and Arkansas (n=1,548). Mexican women were least likely to be adherent to cancer screening tests (clinical breast exam, mammogram, or Pap test). Mexican women also differed from the other sub-groups in terms of sociodemographics, barriers, and interactions within the health care system. Correlates of screening adherence differed by country of origin, with the exception of spouse/partner attendance at the program, which was negatively associated with adherence across several sub-groups. Findings provide important information about Latina sub-group variability that can help inform the development of breast and cervical cancer screening interventions.