Three-component assembly of structurally diverse 2-aminopyrimidine-5-carbonitriles

Cristina Val; Abel Crespo; Vicente Yaziji; Alberto Coelho; Jhonny Azuaje; Abdelaziz El Maatougui; Carlos Carbajales; Eddy Sotelo

doi:10.1021/co4000503

Three-component assembly of structurally diverse 2-aminopyrimidine-5-carbonitriles

ACS Comb Sci. 2013 Jul 8;15(7):370-8. doi: 10.1021/co4000503. Epub 2013 Jun 6.

Authors

Cristina Val¹, Abel Crespo, Vicente Yaziji, Alberto Coelho, Jhonny Azuaje, Abdelaziz El Maatougui, Carlos Carbajales, Eddy Sotelo

Affiliation

¹ Center for Research in Biological Chemistry and Molecular Materials (CIQUS) and ‡Department of Organic Chemistry, Faculty of Pharmacy, University of Santiago de Compostela , Santiago de Compostela, 15782, Spain.

PMID: 23697392
DOI: 10.1021/co4000503

Abstract

An expedient route for the synthesis of libraries of diversely decorated 2-aminopyrimidine-5-carbonitriles is reported. This approach is based on a three-component reaction followed by spontaneous aromatization.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Combinatorial Chemistry Techniques
Nitriles / chemical synthesis*
Nitriles / chemistry
Pyrimidines / chemical synthesis*
Pyrimidines / chemistry
Small Molecule Libraries / chemical synthesis*
Small Molecule Libraries / chemistry

Substances

Nitriles
Pyrimidines
Small Molecule Libraries
2-aminopyrimidine