Renin-angiotensin blockade combined with natriuretic peptide system augmentation: novel therapeutic concepts to combat heart failure

Circ Heart Fail. 2013 May;6(3):594-605. doi: 10.1161/CIRCHEARTFAILURE.112.000289.
No abstract available

Keywords: BNP; angiotensin II; heart failure; natriuretic peptides; neprilysin; renin-angiotensin system.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Alternative Splicing / drug effects
  • Alternative Splicing / physiology
  • Aminobutyrates / therapeutic use
  • Angiotensin Receptor Antagonists / therapeutic use
  • Biphenyl Compounds
  • Designer Drugs / chemistry
  • Designer Drugs / therapeutic use
  • Drug Combinations
  • Drug Therapy, Combination
  • Endothelin-1 / drug effects
  • Heart Failure / drug therapy*
  • Heart Failure / physiopathology
  • Humans
  • Natriuretic Peptide, Brain / physiology
  • Natriuretic Peptide, C-Type / physiology
  • Natriuretic Peptides / chemistry
  • Natriuretic Peptides / physiology*
  • Neprilysin / antagonists & inhibitors
  • Neprilysin / physiology
  • Peptidyl-Dipeptidase A / drug effects
  • Protease Inhibitors / therapeutic use
  • Receptors, Angiotensin / drug effects
  • Renin-Angiotensin System / drug effects*
  • Renin-Angiotensin System / physiology*
  • Snake Venoms / chemistry
  • Tetrazoles / therapeutic use
  • Valsartan

Substances

  • Aminobutyrates
  • Angiotensin Receptor Antagonists
  • Biphenyl Compounds
  • Designer Drugs
  • Drug Combinations
  • Endothelin-1
  • Natriuretic Peptides
  • Protease Inhibitors
  • Receptors, Angiotensin
  • Snake Venoms
  • Tetrazoles
  • Natriuretic Peptide, Brain
  • Natriuretic Peptide, C-Type
  • Valsartan
  • cenderitide
  • Peptidyl-Dipeptidase A
  • Neprilysin
  • sacubitril and valsartan sodium hydrate drug combination