Bioactive dimeric carbazole alkaloids from Murraya koenigii

J Nat Prod. 2013 Jun 28;76(6):993-1000. doi: 10.1021/np300464t. Epub 2013 May 21.

Abstract

Phytochemical studies on the CHCl3 extract of the fruit pulp of Murraya koenigii afforded three new dimeric carbazole alkaloids, bisgerayafolines A-C (1-3). Bisgerayafolines A-C (1-3) are structurally unique dimeric carbazole alkaloids comprising geranyl moieties incorporated in their structures. Compounds 1-3 exhibited various levels of antioxidant, anti-α-glucosidase, DNA binding, and cytotoxic activities and protein interactions.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alkaloids* / chemistry
  • Alkaloids* / isolation & purification
  • Alkaloids* / pharmacology
  • Antineoplastic Agents, Phytogenic* / chemistry
  • Antineoplastic Agents, Phytogenic* / isolation & purification
  • Antineoplastic Agents, Phytogenic* / pharmacology
  • Antioxidants* / chemistry
  • Antioxidants* / isolation & purification
  • Antioxidants* / pharmacology
  • Carbazoles* / chemistry
  • Carbazoles* / isolation & purification
  • Carbazoles* / pharmacology
  • Chloroform / chemistry
  • DNA / drug effects
  • Drug Screening Assays, Antitumor
  • Fruit / chemistry
  • Glycoside Hydrolase Inhibitors*
  • HCT116 Cells
  • HeLa Cells
  • Humans
  • India
  • Molecular Structure
  • Murraya / chemistry*

Substances

  • Alkaloids
  • Antineoplastic Agents, Phytogenic
  • Antioxidants
  • Carbazoles
  • Glycoside Hydrolase Inhibitors
  • bisgerayafoline A
  • bisgerayafoline B
  • bisgerayafoline C
  • Chloroform
  • DNA