Abstract
Phytochemical studies on the CHCl3 extract of the fruit pulp of Murraya koenigii afforded three new dimeric carbazole alkaloids, bisgerayafolines A-C (1-3). Bisgerayafolines A-C (1-3) are structurally unique dimeric carbazole alkaloids comprising geranyl moieties incorporated in their structures. Compounds 1-3 exhibited various levels of antioxidant, anti-α-glucosidase, DNA binding, and cytotoxic activities and protein interactions.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Alkaloids* / chemistry
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Alkaloids* / isolation & purification
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Alkaloids* / pharmacology
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Antineoplastic Agents, Phytogenic* / chemistry
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Antineoplastic Agents, Phytogenic* / isolation & purification
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Antineoplastic Agents, Phytogenic* / pharmacology
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Antioxidants* / chemistry
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Antioxidants* / isolation & purification
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Antioxidants* / pharmacology
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Carbazoles* / chemistry
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Carbazoles* / isolation & purification
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Carbazoles* / pharmacology
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Chloroform / chemistry
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DNA / drug effects
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Drug Screening Assays, Antitumor
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Fruit / chemistry
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Glycoside Hydrolase Inhibitors*
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HCT116 Cells
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HeLa Cells
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Humans
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India
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Molecular Structure
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Murraya / chemistry*
Substances
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Alkaloids
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Antineoplastic Agents, Phytogenic
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Antioxidants
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Carbazoles
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Glycoside Hydrolase Inhibitors
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bisgerayafoline A
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bisgerayafoline B
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bisgerayafoline C
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Chloroform
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DNA