In silico evolution of guiding track designs for molecular shuttles powered by kinesin motors

Lab Chip. 2013 Jul 21;13(14):2827-33. doi: 10.1039/c3lc41103f.

Abstract

Molecular shuttles powered by kinesin motors require guiding tracks to perform specific tasks in nanoscale devices. Here, using our simulation of molecular shuttle movements, we describe an in silico evolutionary design method that makes it possible to automatically design the guiding tracks in accordance with their functions defined by designers. With this design method, we designed two types of pre-existing guiding track modules with improved performances, as well as one with a novel function.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Algorithms
  • Directed Molecular Evolution*
  • Equipment Design
  • Kinesins / chemistry*
  • Microfluidic Analytical Techniques / instrumentation*
  • Microfluidic Analytical Techniques / methods
  • Models, Theoretical*
  • Molecular Dynamics Simulation
  • Nanotechnology / instrumentation*
  • Nanotechnology / methods
  • Polyethylene Glycols / chemistry
  • Silicon Dioxide / chemistry

Substances

  • Polyethylene Glycols
  • Silicon Dioxide
  • Kinesins