PLA2G3 promotes mast cell maturation and function

Nat Immunol. 2013 Jun;14(6):527-9. doi: 10.1038/ni.2612.

Abstract

Mast cell-derived group III phospholipase A2 (PLA2G3) and fibroblast prostaglandin synthase contribute to a PGD2 and mast-cell-DP-1-dependent mast cell-fibroblast paracrine axis that can enhance mast cell maturation and mediator secretion.

Publication types

  • News
  • Comment

MeSH terms

  • Animals
  • Group III Phospholipases A2 / immunology*
  • Humans
  • Mast Cells / immunology*
  • Paracrine Communication / immunology*
  • Prostaglandin D2 / immunology*
  • Receptors, Prostaglandin / immunology*

Substances

  • Receptors, Prostaglandin
  • prostanoid D receptor 1, mouse
  • Group III Phospholipases A2
  • PLA2G3 protein, mouse
  • Prostaglandin D2