Phenol-soluble modulins, hellhounds from the staphylococcal virulence-factor pandemonium

Eleni Tsompanidou; Emma L Denham; Jan Maarten van Dijl

doi:10.1016/j.tim.2013.04.007

Phenol-soluble modulins, hellhounds from the staphylococcal virulence-factor pandemonium

Trends Microbiol. 2013 Jul;21(7):313-5. doi: 10.1016/j.tim.2013.04.007. Epub 2013 May 14.

Authors

Eleni Tsompanidou¹, Emma L Denham, Jan Maarten van Dijl

Affiliation

¹ Department of Medical Microbiology, University of Groningen and University Medical Center Groningen, Hanzeplein 1, P.O. box 30001, 9700 RB Groningen, the Netherlands.

PMID: 23684152
DOI: 10.1016/j.tim.2013.04.007

Abstract

Phenol-soluble modulins are secreted peptides with multiple functions in Staphylococcus aureus pathogenesis and spreading. Recent studies by Otto and coworkers show that these hellhounds of the staphylococcal virulence-factor pandemonium are unleashed through an essential ABC transporter, which represents an exciting new target for stopping the spread of this important pathogen.

Publication types

Research Support, Non-U.S. Gov't
Comment

MeSH terms

ATP-Binding Cassette Transporters / metabolism*
Animals
Bacterial Toxins / metabolism*
Humans
Staphylococcal Skin Infections / microbiology*
Staphylococcus aureus / pathogenicity*

Substances

ATP-Binding Cassette Transporters
Bacterial Toxins