Caenorhabditis elegans reveals novel Pseudomonas aeruginosa virulence mechanism

Trends Microbiol. 2013 Jul;21(7):315-6. doi: 10.1016/j.tim.2013.04.006. Epub 2013 May 14.

Abstract

The susceptibility of Caenorhabditis elegans to different virulent phenotypes of Pseudomonas aeruginosa makes the worms an excellent model for studying host-pathogen interactions. Including the recently described liquid killing, five different killing assays are now available offering superb possibilities for performing high-throughput screens for novel antibiotics using a whole-body infection system.

MeSH terms

  • Animals
  • Caenorhabditis elegans / microbiology*
  • Disease Models, Animal*
  • Host-Pathogen Interactions*
  • Pseudomonas aeruginosa / pathogenicity*
  • Survival Analysis