The two faces of potent antitumor duocarmycin-based drugs: a structural dissection reveals disparate motifs for DNA versus aldehyde dehydrogenase 1 affinity

Angew Chem Int Ed Engl. 2013 Jul 1;52(27):6921-5. doi: 10.1002/anie.201208941. Epub 2013 May 16.
No abstract available

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aldehyde Dehydrogenase 1 Family
  • Alkylating Agents / administration & dosage
  • Alkylating Agents / pharmacology*
  • Antineoplastic Agents / administration & dosage
  • Antineoplastic Agents / pharmacology*
  • Biological Products
  • DNA / chemistry*
  • Duocarmycins
  • Indoles / administration & dosage
  • Indoles / pharmacology*
  • Isoenzymes / chemistry*
  • Proteomics
  • Pyrrolidinones / administration & dosage
  • Pyrrolidinones / pharmacology
  • Retinal Dehydrogenase / chemistry*
  • Structure-Activity Relationship

Substances

  • Alkylating Agents
  • Antineoplastic Agents
  • Biological Products
  • Duocarmycins
  • Indoles
  • Isoenzymes
  • Pyrrolidinones
  • DNA
  • Aldehyde Dehydrogenase 1 Family
  • Retinal Dehydrogenase
  • duocarmycin A