We conducted clinical research at Jichi Medical University Hospital psychiatric ward on 38 patients over the age of 40 with late-onset schizophrenia and on 278 patients under the age of 40 with early-onset schizophrenia. Cases with onset after age 40 reported in 12% of the total population. Female cases were 20.4%, and the result was significantly higher than the male cases of 4.3%. Paranoid type was 55.3% of the total population of the late-onset cases, and it was significantly higher than the early-onset cases of younger than 40 years old. 55.3% of late-onset cases were combined with depressive symptoms, and they rated significantly higher than early-onset cases.