Synthesis of Some New 3, 5-Bis (substituted) Pyrazoles and Isoxazoles Based on (N'(1)E, N'(3)E)- N'(1), N'(3)-Bis (3, 4, 5-substitutedbenzlidene) Malonohydrazide under Solvothermal Conditions

Ebraheem Abdu Musad; Kuriya Madavu Lokanatha Rai; Kullaiah Byrappa

Synthesis of Some New 3, 5-Bis (substituted) Pyrazoles and Isoxazoles Based on (N'(1)E, N'(3)E)- N'(1), N'(3)-Bis (3, 4, 5-substitutedbenzlidene) Malonohydrazide under Solvothermal Conditions

Int J Biomed Sci. 2010 Mar;6(1):45-8.

Authors

Ebraheem Abdu Musad¹, Kuriya Madavu Lokanatha Rai, Kullaiah Byrappa

Affiliation

¹ Department of Chemistry, University of Mysore, Manasagangotri, Mysore, India;

PMID: 23675175
PMCID: PMC3614729

Abstract

The new 3,5-(substituted) pyrazoles and isoxazoles were prepared by reaction of (N'(1)E, N'(3)E)- N'(1), N'(3)-bis (3,4,5-substitutedbenzylidene)malonohydrazide with hydrazine hydrate and hydroxylamine hydrochloride respectively under solvothermal conditions involving an ecofriendly method without any environmental pollution, the yield are in the range of 75-96%. The structure of the new compounds were established using elemental analysis, IR, (1)H NMR, (13)C NMR.

Keywords: isoxazoles; pyrazoles; solvothermal.