[Pharmacokinetic effect of Sappan Lignum on hydroxysafflor yellow A in Carthami Flos]

Zhongguo Zhong Yao Za Zhi. 2013 Jan;38(2):269-72.
[Article in Chinese]

Abstract

Objective: To investigate the pharmacokinetic effect of Sappan Lignum on hydroxysafflor yellow A (HSYA) in Carthami Flos.

Method: Concentration of HSYA in rat plasma was detected by RP-HPLC after rats were orally administered with extracts of Carthami Flos or Carthami Flos combined with Sappan Lignum. Pharmacokinetic parameters were calculated by DAS 2.0 pharmacokinetic software.

Result: In vivo pharmacokinetic models of HSYA were two-compartment open models in both of the Carthami Flos group and the Carthami Flos combined with Sappan Lignum group. After compatibility, HSYA showed a significant lower in apparent volumes of distribution of t(1/2Ka), t(1/2alpha) and V1/F, with slight advance in T(max).

Conclusion: Sappan Lignum can accelerate absorption, distribution and metabolic process of HSYA in vivo and reduce its accumulation in vivo.

Publication types

  • English Abstract

MeSH terms

  • Administration, Oral
  • Animals
  • Caesalpinia / chemistry*
  • Carthamus tinctorius / chemistry*
  • Chalcone / administration & dosage
  • Chalcone / analogs & derivatives*
  • Chalcone / isolation & purification
  • Chalcone / pharmacokinetics
  • Chromatography, High Pressure Liquid
  • Drug Synergism
  • Drugs, Chinese Herbal / administration & dosage
  • Drugs, Chinese Herbal / isolation & purification
  • Drugs, Chinese Herbal / pharmacokinetics*
  • Female
  • Flowers / chemistry
  • Male
  • Quinones / administration & dosage
  • Quinones / isolation & purification
  • Quinones / pharmacokinetics*
  • Rats
  • Rats, Sprague-Dawley
  • Specific Pathogen-Free Organisms
  • Wood / chemistry

Substances

  • Drugs, Chinese Herbal
  • Quinones
  • hydroxysafflor yellow A
  • Chalcone