Pulse radiolysis studies on the reaction of the reduced vitamin B₁₂ complex Cob(II)alamin with superoxide

Chembiochem. 2013 Jun 17;14(9):1081-3. doi: 10.1002/cbic.201300229. Epub 2013 May 13.

Abstract

O₂.- scavenger: The rate constant for the rapid reaction of the ROS superoxide with the reduced vitamin B₁₂ radical complex cob(II)alamin was directly determined to be 3.8×10(8) M⁻¹ s⁻¹. This rate was independent of pH over the range 5.5-8.7. These results have implications for studying the use of B₁₂ supplements to combat diseases associated with oxidative stress.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Hydrogen-Ion Concentration
  • Kinetics
  • Oxidation-Reduction
  • Superoxides / chemistry*
  • Vitamin B 12 / analogs & derivatives*
  • Vitamin B 12 / chemistry

Substances

  • Superoxides
  • cob(II)alamin
  • Vitamin B 12