Neuroprotective compounds from the bulbs of Lycoris radiata

Fitoterapia. 2013 Jul:88:82-90. doi: 10.1016/j.fitote.2013.05.006. Epub 2013 May 10.

Abstract

Three new alkaloids (1-3) and one new phenolic glycoside (4), together with twenty five known alkaloids (5-29), were isolated from the bulbs of Lycoris radiata collected from Huaihua county of Hunan province, China. Their structures were elucidated on the basis of comprehensive NMR and MS spectroscopic analysis. The isolated alkaloids were evaluated for their neuroprotective activities against CoCl2, H2O2 and Aβ(25-35)-induced SH-SY5Y cell injuries. Compounds 1-3 showed significant neuroprotective effects against H2O2 or CoCl2-induced SH-SY5Y cell death, while compound 3 exhibited significant neuroprotective effects against Aβ(25-35)-induced SH-SY5Y cell injury. The known alkaloids 5-29 also exhibited similar bioactivities of different degrees. These findings highlight the fact that the over 100 Amaryllidaceae alkaloids may have a big potential to neuroprotective activity.

Keywords: Amaryllidaceae alkaloids; Lycoris radiata; Neuroprotective activity.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amaryllidaceae Alkaloids / chemistry
  • Amaryllidaceae Alkaloids / isolation & purification
  • Amaryllidaceae Alkaloids / pharmacology
  • Amyloid beta-Peptides
  • Cell Death
  • China
  • Cobalt
  • Humans
  • Hydrogen Peroxide
  • Indole Alkaloids / chemistry
  • Indole Alkaloids / isolation & purification
  • Indole Alkaloids / pharmacology*
  • Lycoris / chemistry*
  • Molecular Structure
  • Neuroprotective Agents / chemistry
  • Neuroprotective Agents / isolation & purification
  • Neuroprotective Agents / pharmacology*
  • Plant Extracts / chemistry
  • Plant Extracts / pharmacology*
  • Plant Roots / chemistry

Substances

  • Amaryllidaceae Alkaloids
  • Amyloid beta-Peptides
  • Indole Alkaloids
  • Neuroprotective Agents
  • Plant Extracts
  • Cobalt
  • Hydrogen Peroxide
  • cobaltous chloride