HLA-B*58:01 strongly associates with allopurinol-induced adverse drug reactions in a Japanese sample population

J Dermatol Sci. 2013 Aug;71(2):150-2. doi: 10.1016/j.jdermsci.2013.04.013. Epub 2013 Apr 19.

Authors

Hiroyuki Niihara, Sakae Kaneko, Takahumi Ito, Takashi Sugamori, Nobuyuki Takahashi, Kunie Kohno, Eishin Morita

PMID: 23669020
DOI: 10.1016/j.jdermsci.2013.04.013

No abstract available

Publication types

Letter
Research Support, Non-U.S. Gov't

MeSH terms

Aged
Aged, 80 and over
Allopurinol / adverse effects*
Asian People
Case-Control Studies
Drug-Related Side Effects and Adverse Reactions
Erythema / drug therapy
Erythema / genetics
Female
Gout Suppressants / adverse effects
HLA-B Antigens / genetics*
Humans
Japan
Male
Odds Ratio
Pharmacogenetics
Stevens-Johnson Syndrome / drug therapy
Stevens-Johnson Syndrome / genetics

Substances

Gout Suppressants
HLA-B Antigens
HLA-B*58:01 antigen
Allopurinol