Prediction of HIV drug resistance based on virologic, immunologic, clinical, and/or adherence criteria in the Stratall ANRS 12110/ESTHER trial in Cameroon

Charlotte Boullé; Charles Kouanfack; Gabrièle Laborde-Balen; Avelin Fobang Aghokeng; Sylvie Boyer; Maria Patrizia Carrieri; Serge Kazé; Jean-Marc Mben; Marlise Dontsop; Bruno Spire; Martine Peeters; Eitel Mpoudi-Ngolé; Eric Delaporte; Christian Laurent; Stratall ANRS 12110/ESTHER Study Group

doi:10.1093/cid/cit323

Prediction of HIV drug resistance based on virologic, immunologic, clinical, and/or adherence criteria in the Stratall ANRS 12110/ESTHER trial in Cameroon

Clin Infect Dis. 2013 Aug;57(4):604-7. doi: 10.1093/cid/cit323. Epub 2013 May 10.

Authors

Charlotte Boullé¹, Charles Kouanfack, Gabrièle Laborde-Balen, Avelin Fobang Aghokeng, Sylvie Boyer, Maria Patrizia Carrieri, Serge Kazé, Jean-Marc Mben, Marlise Dontsop, Bruno Spire, Martine Peeters, Eitel Mpoudi-Ngolé, Eric Delaporte, Christian Laurent; Stratall ANRS 12110/ESTHER Study Group

Collaborators

Stratall ANRS 12110/ESTHER Study Group:
M Biwolé-Sida, C Kouanfack, S Koulla-Shiro, A Bourgeois, E Delaporte, C Laurent, M Peeters, G Laborde-Balen, M Dontsop, S Kazé, J-M Mben, A Aghokeng, M G Edoul, E Mpoudi-Ngolé, M Tongo, S Boyer, M P Carrieri, F Marcellin, J-P Moatti, B Spire, C Abé, S-C Abega, C-R Bonono, H Mimcheu, S Ngo Yebga, C Paul Bile, S Abada, T Abanda, J Baga, P Bilobi Fouda, P Etong Mve, G Fetse Tama, H Kemo, A Ongodo, V Tadewa, H D Voundi, A Ambani, M Atangana, J-C Biaback, M Kennedy, H Kibedou, F Kounga, M Maguip Abanda, E Mamang, A Mikone, S Tang, E Tchuangue, S Tchuenko, D Yakan, J Assandje, S Ebana, D Ebo'o, D Etoundi, G Ngama, P Mbarga Ango, J Mbezele, G Mbong, C Moung, N Ekotto, G Nguemba Balla, G Ottou, M Tigougmo, R Beyala, B Ebene, C Effemba, F Eyebe, M-M Hadjaratou, T Mbarga, M Metou, M Ndam, B Ngoa, E B Ngock, N Obam, A M Abomo, G Angoula, E Ekassi, J J Lentchou, I Mvilongo, J Ngapou, F Ntokombo, V Ondoua, R Palawo, S Sebe, E Sinou, D Wankam, I Zobo, B Akono, A L Ambani, L Bilock, R Bilo'o, J Boombhi, F X Fouda, M Guitonga, R Mad'aa, D R Metou'ou, S Mgbih, A Noah, M Tadena, G Ambassa Elime, A A Bonongnaba, E Foaleng, R M Heles, R Messina, O Nana Ndankou, S A Ngono, D Ngono Menounga, S S Sil, L Tchouamou, B Zambou, R Abomo, J Ambomo, C Beyomo, P Eloundou, C Ewole, J Fokom, M Mvoto, M Ngadena, R Nyolo, C Onana, A Oyie, P Antyimi, S Bella Mbatonga, M Bikomo, Y Molo Bodo, S Ndi Ntang, P Ndoudoumou, L Ndzomo, S O Ngolo, M Nkengue, Y Tchinda

Affiliation

¹ Institut de Recherche pour le Développement (IRD), University Montpellier 1, UMI 233 TransVIHMI, Montpellier, France. charlotte.boulle@ird.fr

PMID: 23667264
DOI: 10.1093/cid/cit323

Abstract

Our study in Cameroonian rural district hospitals showed that the immunologic and clinical failure criteria had poor performance to identify human immunodeficiency virus drug resistance in a timely manner. Switching to second-line antiretroviral therapy after 2 consecutive viral loads ≥5000 copies/mL, as recommended by the World Health Organization, appeared to be the most appropriate strategy.

Keywords: Africa; HIV; failure; resistance; switch.

Publication types

Evaluation Study
Research Support, Non-U.S. Gov't

MeSH terms

Adult
Anti-HIV Agents / therapeutic use*
CD4 Lymphocyte Count
Cameroon
Decision Support Techniques*
Drug Resistance, Viral*
Female
HIV Infections / drug therapy*
HIV Infections / immunology
HIV Infections / pathology
HIV Infections / virology
Hospitals
Humans
Male
Medication Adherence / statistics & numerical data*
Middle Aged
Rural Population
Viral Load*

Substances

Anti-HIV Agents