Abstract
A series of novel nitric oxide (NO) donating triazole/oxime hybrids was prepared and evaluated for their anti-inflammatory activity. Most of the tested compounds showed significant anti-inflammatory activity using carrageenan-induced rat paw edema method compared to indomethacin. Calculation of the ulcer indices and histopathological investigation indicated that the prepared NO-donating oximes exhibited less ulcerogenicity compared to their intermediate ketones and indomethacin. The NO-donating oxime 6i revealed significant activity against renal cancer A498 cell lines with 50.52 cell growth inhibition.
Copyright © 2013 Elsevier Ltd. All rights reserved.
MeSH terms
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Animals
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Anti-Inflammatory Agents, Non-Steroidal / chemical synthesis
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Anti-Inflammatory Agents, Non-Steroidal / chemistry*
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Anti-Inflammatory Agents, Non-Steroidal / pharmacology*
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Anti-Inflammatory Agents, Non-Steroidal / therapeutic use
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Antineoplastic Agents / chemical synthesis
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Antineoplastic Agents / chemistry*
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Antineoplastic Agents / pharmacology*
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Antineoplastic Agents / therapeutic use
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Cell Line, Tumor
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Edema / drug therapy
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Humans
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Kidney Neoplasms / drug therapy
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Male
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Nitric Oxide / administration & dosage
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Nitric Oxide Donors / chemical synthesis
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Nitric Oxide Donors / chemistry*
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Nitric Oxide Donors / pharmacology*
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Nitric Oxide Donors / therapeutic use
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Oximes / chemical synthesis
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Oximes / chemistry
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Oximes / pharmacology
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Oximes / therapeutic use
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Rats
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Stomach / drug effects
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Triazoles / chemical synthesis
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Triazoles / chemistry
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Triazoles / pharmacology
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Triazoles / therapeutic use
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Ulcer / chemically induced
Substances
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Anti-Inflammatory Agents, Non-Steroidal
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Antineoplastic Agents
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Nitric Oxide Donors
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Oximes
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Triazoles
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1,2,4-triazole
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Nitric Oxide